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pentobarbital will lower the extent or effect of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Outcome of coadministering a solid CYP3A4 inducer with fedratinib has not been researched.fentanyl transmucosal and pentobarbital both improve sedation. Stay away from or Use Alternate Drug. Lim